Assessment of Ureteroscopy During Pregnancy

Assessment of Ureteroscopy During PregnancyINTRODUCTIONUrolithiasis during maternity is an extraordinary origin, with an incidence of 0.026 to 0.531 percent in the medical literature (1). nephritic colic is the nigh common presentation of urolithiasis, as well as the to the highest degree common nonobstetric ca intention of infirmaryization during gestation period and a predetermining factor of immature labor especi ally if accompanied by urinary package infection(2,3). In approximately 70 percent of the cases the match is passed spontaneously with the subprogram of analgesics and hydration. (4-7) In other cases the onset of infection, fever and refractory ureteral colic require a variety of endourologic actions such as stent placement treatment(8).The diagnosis of ureteral calculi in meaning(a) women is often difficult beca enforce of the serious luck of mental pictures presented by radiation exposure, especially during the scratch line trimester. As such, the diagnos is is best based on clinical data, urinalysis and ultrasound examinations however, ultrasound does non always go forth a overhear diagnostic picture, even though at time color flux Doppler ultrasound whitethorn be effectual (9). Further diagnostic efforts are indicated when the patient has intrac give in pain or upper urinary tract infection, or if nephritic function is decreasing for which a more comminuted diagnosis aims at specific treatment. In this situation ureteroscopy was considered a hireful option, since it combines the diagnostic mapping with definitive treatment(10).Beca ingestion of the recent advances in the techniques and technology in the field of ureteroscopy, the new and thinner semirigid and flexible ureteroscopes film allowed sluttish access to the ureter without any need for dilation and with minimal role. (11) Ureteroscopy can be performed successfully for ureteral calculi in meaning(a) women and stones can be removed with the stone basket or fr agmented with ultrasonic ballistic or laser lithotriptors below sedation-analgesia (12-14). Ureteroscopy can be performed with greater care when the patient is to a lower place sedation-analgesia than if spinal or general anesthesia is apply, since the patient can get together during the procedure. Therefore, sedation-analgesia may be preferred when ureteroscopy is performed in pregnant patients (15,16). For reasons mentioned above, we have started use of minureteroscopes for managing pregnant patients with mingled stone disease not responding to medical measures and herein we present our experience with 15 patients.PATIENTS AND METHODSBetween 2000 and 2005 we performed ureteroscopy and ureterolithotripsy on 15 pregnant patients 21 to 32 years old. all(prenominal) patients down the stairswent extensive diagnostic rating including urinalysis, urine culture and antibiogram, complete blood picture, bleeding and coagulation times, renal and liver function outpourings as well as , complete abdomino-pelvic ultrasound, and an accurate obstetrical examination to evaluate the fetal condition.The women were placed on the operating table in an oblique position with the left side down when needed to decrease the pressure of the pregnant uterus on the inferior mineral vein cava. Sedation-analgesia with 2.5mg midazolam and 50 mg pethidine intravenously was apply in the world-class 7 patients. In the bonding 8 cases 10 mg nalbuphine HCL was used in addition to midazolam. Prophylactic therapy with ampicillin/ sulbactum 1.5gm was administered before the procedure. Ureteroscopy was performed with ultrasound monitoring. The use of ionizing radiation was avoided before, during and after the procedures. Constant obstetrical monitoring was available end-to-end the procedures.All patients on a lower floorwent ureteroscopy with thin rigid 7.0F ureteroscopes without dilation of the ureteral meatus. We used either the micro-six ACMI ureteroscope or Karl-Storz 6.9 F semir igid ureteroscope. Floppy tip guide wire 0.035 was inserted over a 6 F open tip ureteric catheter through the 22 F cystoscopy. The wire was advanced first to the collecting system where it has been fixed. In cases with difficult guide wire insertion through the cystoscope, direct ureteroscopy was so performed and a safety wire was inserted through the ureteroscope. Then the ureteroscope was advanced alongside the wire and visualization of the whole ureter was done. Once a stone is figure a decision was made in regard to the best representation of extraction. Factors, such as size, amount of speculation, degree of impaction, location within the ureter and condition of the distal ureter, were considered. Our method of choice was the use of the stone basket infra direct vision. If the size of the stone precluded the use of the basket technique, we elected to break down the stone using pneumatic intracorporeal lithotripsy. At the end of the procedure, a forficate pigtail ureteral stent or external ureteral catheter was placed in the ureter to avoid partial urinary obstruction and flank pain due to mucosal edema. If external stent was used, it is level(p) to a Foley catheter. The Foley and ureteral catheters were removed within 1 to 2 age.The operating time, hospital stay, perioperative and postoperative complications, outcome of the pregnancies and deliveries, and condition of the neonates postpartum were all recorded. All women underwent throw and abdomino-pelvic ultrasound 6weeks after delivery.RESULTSThe mean age of our patients was 25.3 years (range 21-32 years) and the mean maternal quality time was 28 weeks (range16-32 weeks). The main presenting symptoms and indication of surgical intervention were continual ureteric colic not responding to analgesics, fever, recurrent UTIs, and hematuria (table1).Urine culture was affirmatory for ampicillin-sensitive strains of E-coli and proteus vulgaris in 3 patients. Macroscopic hematuria was found in 3 pati ents while microscopic hematuria was present in in 2 patients. Leukocytosis was found in 2 patients. Ultrasonography showed dilation of the renal pelvis in all cases and stones were identified in 8 cases. speed ureteral stones were found in 3 patients while lower ureteric stones were diagnosed in 5 patients. The mean stone size diagnosed with ultrasound was 0.6cm (range from 0.5-1.2 cm). Ureteroscopy was done for all cases with the total ureter examined without the need for ureteric orifice dilatation. Stones were extracted from the lower ureter by Dormia basket in 7 patients. Stone fragmentation with the pneumatic lithotriptor was used for stones above the iliac vessels in 6 cases and no stones have been found in 2 patients (table 2).A recapitulate pigtail ureteral catheter was inserted in 8 cases (6 patients with fragmented calculi and the 2 cases with no substantiate stone) and ensured to be in the proper position by watching its distal end in the bladder and monitoring of th e upper end curled in the renal pelvis through ultrasound examination. In the 7 patients with extracted calculi, a 6 F ureteric catheter was inserted for one or two days postoperatively.Duration of the procedure ranged from 15-30 minutes and obstetric monitoring showed no signs of fetal distress or pre-term delivery. No complications encountered and convalescence was uneventful. Patients who had pain were improved unusually and fever disappeared within the next 24 hours after the procedure. Patients were discharged home 72 days after the procedure and the external ureteric catheter was removed. Patients with double J stenting had their stent removed after labor in the two patients with negative ureteroscopic determination while patients underwent stone fragmentation had stent withdrawal after 3 weeks. All pregnancies progressed to full term delivery. Five patients had an elective Cesarean section as they had a history of previous section and no fetal abnormalities were detected. The follow up PUT and U/S performed 6 weeks postpartum revealed disappearance of renal pelvis dilatation and no calculi were found in all patients.DISCUSSIONThe first publications on ureteroscopic diagnosis and management of ureteral calculi during pregnancy appeared in 1988.12 The differential diagnosis of ureteral calculi versus physiological dilatation in pregnancy was rendered doable by this procedure with great assistance in management. Using ureteroscopy and stent placement, under ultrasound monitoring, was an important step forward in stone manipulation during pregnancy (12,13). It was alleged(a) that anatomic distortions caused by the fetal presence would not allow the introduction of the rigid ureteroscope and this procedure could be of high risk to the pregnancy. However, it was proved that the natural ureteral dilation in pregnancy facilitates the introduction of the ureteroscope and the procedure could be performed easily by following the usual rules, except for the u se of fluoroscopy (17).The diagnosis of ureteral calculi in pregnant women is often difficult because of the serious risks presented by radiation exposure, especially during the first trimester(9). Several investigators have highlighted the problems related to the exposure of the pregnant patients to x-rays in regard to the incidence of tumors in children who were irradiated during fetal life(9,18). Therefore, the use of x-ray for the diagnosis or management of stones during pregnancy remains controversial (19).Ultrasonography is the main diagnostic method in these cases, because besides its non- encroaching(a) nature, it does not use radiation, and is universally available (3,8). However, Ultrasound does not always provide a clear diagnostic picture, even though at times color flow Doppler ultrasound by using resistive indices may be useful (10). In our study, we avoided the use of x-ray for the diagnosis of stones during pregnancy and we depend mainly on clinical diagnosis and ult rasound examination. Renal pelvic dilatation alone or combined with calyceal dilatation was diagnosed by U/S in our patients and ureteral stones were found in 8 (61.5%) out of 13 ureteroscopically confirmed stones. Although U/S is safe under all circumstances of pregnancy, its utilization in diagnosing obstruction is of restrict value owing to its sub-optimal view of the ureter and presence of hydroureteronephrosis as a physiologic concomitant of pregnancy.Hematuria, both macro and microscopic, is a normal sign, but is not specific (4, 8, 20) while urinary tract infection is present in 20 to 45% of the cases of calculus during pregnancy (1,21-22). Among our patients, hematuria was present in 5 (33.3%) patients and asymptomatic bacteriuria was detected in 4 (26.7%) patients while pyelonephritis complicated 2 (13.3%) pregnant women.In the early protocols for stone management in pregnant patients, the double pigtail catheters were used to treat renal dilatation and in cases of failur e, an ultrasound guided nephrostomy was preferred over the risks inherent with ureteroscopy (19). Stents and drains may have many disadvantages including accidental dislodgment, obstruction or bladder irritability and dreadful symptoms (1). In addition, incrustation on double pigtail stents with resultant obstruction is frequent in pregnant women and it is advised that stents should be changed every few weeks during pregnancy. The repeat insertions of tubes and stents may have potential risks that may be comparable to the risk associated with ureteroscopy performed as a single procedure. (11-14). In the present series, we have used the 7F semirigid ureteroscope, without need of dilating the ureteral meatus in any of the cases. In fact, this procedure is simpler than it was supposed in the past.It was suggested that pregnant patients with ureteral calculus and fever should be treated with antibiotics and drain by a double-J catheter. The advantage of this method is that it is an e fficient and less invasive method. Ureteroscopy was not advised in these patients because ureteral manipulation and liquid injection under pressure in the excretory system may lead to bacteruria and airing of the infection (23). However, stent should be left until the end of pregnancy, which can be a predisposing factor to infections and may cause vesical discomfort in most patients. We have used ureteroscopy in 2 pregnant patients with pyelonephritis and obstructing ureteral calculi and stones were removed and double J stents were inserted for 3 weeks without complications. Those patients were given antibiotics according to culture and sensitivity test prior to the procedure and during ureteroscopy fluid pressure was kept at marginal and non-refluxing double J stents were used.A further advantage of ureteroscopy as a diagnostic and therapeutic option is that general anesthesia can be avoided during pregnancy. With the application of mini-ureteroscopes and small instruments, gener al anesthesia was replaced by sedation analgesia among our patients. This sentiment has already been highlighted by others who reported on flexible ureteroscopy (12).In conclusion, ureteroscopy during pregnancy can be performed safely under sedation analgesia for diagnosis and remotion of ureteral calculi in cases of failure of conservative management in experienced centers with the use of miniureteroscopes and without using fluoroscopy.